Progressive respiratory distress caused by a laryngeal histiocytic sarcoma in a European rabbit (Oryctolagus cuniculus)

نویسندگان

چکیده

Histiocytic sarcoma (HS) represents a rare type of malignant disease, characterized by neoplastic proliferation interstitial dendritic cells (iDCs). In rabbits, there are only two previous reports HS with pulmonary and cutaneous primary localizations. A 2-year-old, male, European rabbit (Oryctolagus cuniculus) clinical history chronic respiratory distress progressive weight loss was necropsied. Postmortem examination revealed gray-white, well-demarcated ovoid mass that deformed the ventral region larynx. Similar nodules were identified in both lungs. Histologically, laryngeal composed dense sheets histiocytes marked atypia multinucleated cells. Immunohistochemically, intensely positive for Iba1, CD1a, vimentin, occasionally E-cadherin, negative multi-cytokeratin. diagnosis multiple metastases made. To authors' knowledge, histiocytic tumor has not been previously reported rabbits.

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ژورنال

عنوان ژورنال: Ankara Universitesi Veteriner Fakultesi Dergisi

سال: 2021

ISSN: ['1300-0861', '1308-2817']

DOI: https://doi.org/10.33988/auvfd.777459